کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022589 1580683 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease
چکیده انگلیسی
Cortical and subcortical dysfunction in schizophrenia includes altered expression of RNA and proteins involved in neurotransmission, metabolism, myelination and other functions. The molecular mechanisms underlying this type of alteration remain largely unknown. Here, we summarize findings from postmortem brain studies and argue that transcriptional dysregulation, including changes in DNA and histone modifications involved in epigenetic control of gene expression, as well as microRNA-mediated post-transcriptional mechanisms contribute to the neurobiology of schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 46, Issue 2, May 2012, Pages 255-262
نویسندگان
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