Psychosine induces the dephosphorylation of neurofilaments by deregulation of PP1 and PP2A phosphatases

►Axonal diameter is decreased in the nerves of the mouse model of Krabbe disease. ►Neurofilaments are less phosphorylated in the Twitcher mouse. ►Protein phosphatases 1 and 2A are responsible for the NF dephosphorylation in the Twitcher mouse. ►Psychosine causes the dephosphorylation of NFs by inducing the activity of protein phosphatases in vitro.