Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury

► MIF/TKP reduces TNF-α production following spinal cord injury (SCI). ► Suppression of macrophages/microglia reduces astrogliosis and CSPG expression. ► Inhibition of macrophages/microglia reduces oligodendrocyte death and myelin loss. ► MIF/TKP prevents axonal die-back.