Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice

► Mice were assessed 6 months after exposure to subchronic ketamine. ► Ketamine-treated mice had reductions in N40 and P80 ERPs and evoked theta power. ► Subchronic ketamine produced disruptions in reversal learning and spatial memory. ► Ketamine-treated mice had increased GFAP, decreased GLT-1 and no change in NeuN.