کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022815 1580700 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
L1cam acts as a modifier gene during enteric nervous system development
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
L1cam acts as a modifier gene during enteric nervous system development
چکیده انگلیسی
►L1cam interacts with the transcription factor, Sox10, to significantly increase the incidence of aganglionosis. ►L1cam does not interact with members of the Gdnf signaling pathway. ►Interactions between L1cam and Sox10 significantly disrupt neural crest migration within the developing gut. ►Interactions between L1cam and Sox10 result in neural crest cells undergoing excessive cell death prior to entering the gut. ►Sox10 directly regulates L1cam expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 40, Issue 3, December 2010, Pages 622-633
نویسندگان
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