کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6052085 1583344 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic effect between clove oil and its major compounds and antibiotics against oral bacteria
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Synergistic effect between clove oil and its major compounds and antibiotics against oral bacteria
چکیده انگلیسی

BackgroundEssential oils have been found to be antibacterial, antifungal, spasmolytic, and antiplasmodial activity and therapeutic effect in cancer treatment.Objective and designIn this study, clove oil and its major compounds, eugenol and β-caryophyllene were evaluated against oral bacteria, either alone or in combination with ampicillin or gentamicin, via checkerboard and time kill assay.ResultsThe antibacterial activity of the clove oil was higher than β-caryophyllene but was similar to eugenol against all tested oral bacteria. Furthermore, the MIC and MBC were reduced to one half-one sixteenth as a result of the combination of clove oil or eugenol with antibiotics. The synergistic interaction was verified by time kill studies using the clove oil or eugenol with antibiotics. 60 min of treatment with MIC of the clove oil or eugenol with ampicillin or gentamicin resulted in an increase in the rate of killing in units of CFU/mL to a greater degree than was observed with alone.ConclusionThe results suggest that the clove oil and eugenol could be employed as a natural antibacterial agent against cariogenic and periodontopathogenic bacteria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 56, Issue 9, September 2011, Pages 907-916
نویسندگان
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