Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV

- Diagnosis of severe dengue was less frequent in DENV/HIV coinfection.
- Coinfected patients presented low CD4+ T cells% with increased in CCR5 expression.
- An increased CD107a expression on both T subsets was observed during coinfection.
- Chemokines IP-10 and IL-8 were significantly altered in plasma of coinfected patients.
- Cytokines involved in dengue pathogenesis were also increased during coinfection.

The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV.