کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6092330 | 1209777 | 2015 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Zebrafish: An Important Tool for Liver Disease Research
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کلمات کلیدی
GFPdimethylbenzanthraceneFLDUPRDMBANACCyPDPFHCC - HCCN-acetylcysteine - N-استیل سیستئینROS - ROSALD - آدرنولکودیستروفیDrug-induced liver injury - آسیب کبدی ناشی از مواد مخدرRegeneration - باززاییalcoholic liver disease - بیماری کبدی الکلیFatty liver disease - بیماری کبدی چربDILI - دیلیDevelopment - رشدdays postfertilization - روز بعد از بارداریLiver cancer - سرطان کبدToxicology - سمشناسیCytochrome P450 - سیتوکروم پی۴۵۰endoplasmic reticulum - شبکه آندوپلاسمی Technology - فناوری (تکنولوژی)Unfolded protein response - پاسخ پروتئین آشکارgreen fluorescent protein - پروتئین فلورسنت سبزHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)Reactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Danio rerio) have traditionally been used to study embryonic development but are also important to the study of liver disease. Zebrafish embryos develop rapidly; all of their digestive organs are mature in larvae by 5 days of age. At this stage, they can develop hepatobiliary diseases caused by developmental defects or toxin- or ethanol-induced injury and manifest premalignant changes within weeks. Zebrafish are similar to humans in hepatic cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate liver diseases. Genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of liver disease. We can perform genetic screens to identify novel genes involved in specific disease processes and chemical screens to identify pathways and compounds that act on specific processes. We review how studies of zebrafish have advanced our understanding of inherited and acquired liver diseases as well as liver cancer and regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 149, Issue 6, November 2015, Pages 1361-1377
Journal: Gastroenterology - Volume 149, Issue 6, November 2015, Pages 1361-1377
نویسندگان
Wolfram Goessling, Kirsten C. Sadler,