Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus

► An inverse correlation between circulating anti-dsDNA antibodies and chromatin in SLE patients. ► Circulating anti-dsDNA antibodies correlates with kidney deposition of chromatin containing IgG. ► Anti-dsDNA antibodies and circulating chromatin may indicate immune deposition in the kidney.