کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6117539 1217240 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-peptidic δ-opioid receptor antagonists suppress mitogen-induced tryptophan degradation in peripheral blood mononuclear cells in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Non-peptidic δ-opioid receptor antagonists suppress mitogen-induced tryptophan degradation in peripheral blood mononuclear cells in vitro
چکیده انگلیسی
Opioid receptors are expressed not only on neuroendocrine cells but also on immunocompetent cells such as lymphocytes, monocytes and macrophages. μ-Opioid receptor agonists were found to exert immunosuppressive effects, whereas δ-opioid receptor agonists have been shown to act as immunostimulants. δ-Opioid receptor agonists stimulate T and B cells and activate granulocytes and monocytes, conversely, immunostimulation can be blocked by the non-peptidic δ-opioid receptor antagonist (NTI). We investigated the impact of NTI and of the two structurally related compounds HS-378 and HS-459 on degradation of tryptophan and formation of neopterin in mitogen-stimulated human peripheral blood mononuclear cells (PBMC). Both these biochemical pathways were found to be suppressed by all three opioid receptor antagonists, HS-378 and HS-459 exhibiting slightly greater potency than NTI. The suppression of tryptophan degradation suggests that the tested δ-opioid antagonists are able to influence the serotonergic system via a non-opioid action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 118, Issue 1, 15 June 2008, Pages 82-87
نویسندگان
, , , , , ,