کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6119338 | 1592304 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms
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کلمات کلیدی
OVACTLA-4B7-H4T1DPLPEAETCrMBPCFAcomplete Freund's adjuvant - adjuvant دوست کاملCD4+ T-cell - CD4 + T-cellregulatory T-cells - T-cell های نظارتیOvalbumin - اوبلبومینautoimmunity - خودایمنیCNS - دستگاه عصبی مرکزیType I diabetes - دیابت نوع Icentral nervous system - سیستم عصبی مرکزیMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)Myelin basic protein - پروتئین پایه میلینMyelin proteolipid protein - پروتئین پروتئین مایید پروتئینT cell receptor - گیرنده سلول T
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We evaluated the therapeutic efficacy and mechanisms of action of both mouse and human B7-H4 Immunoglobulin fusion proteins (mB7-H4Ig; hB7-H4Ig) in treating EAE. The present data show that mB7-H4Ig both directly and indirectly (via increasing Treg function) inhibited CD4+ T-cell proliferation and differentiation in both Th1- and Th17-cell promoting conditions while inducing production of IL-10. B7-H4Ig treatment effectively ameliorated progression of both relapsing (R-EAE) and chronic EAE correlating with decreased numbers of activated CD4+ T-cells within the CNS and spleen, and a concurrent increase in number and function of Tregs. The functional requirement for Treg activation in treating EAE was demonstrated by a loss of therapeutic efficacy of hB7-H4Ig in R-EAE following inactivation of Treg function either by anti-CD25 treatment or blockade of IL-10. Significant to the eventual translation of this treatment into clinical practice, hB7-H4Ig similarly inhibited the in vitro differentiation of naïve human CD4+ T-cells in both Th1- and Th17-promoting conditions, while promoting the production of IL-10. B7-H4Ig thus regulates pro-inflammatory T-cell responses by a unique dual mechanism of action and demonstrates significant promise as a therapeutic for autoimmune diseases, including MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 44, August 2013, Pages 71-81
Journal: Journal of Autoimmunity - Volume 44, August 2013, Pages 71-81
نویسندگان
Joseph R. Podojil, Linda N. Liu, Shannon A. Marshall, Ming-Yi Chiang, Gwen E. Goings, Lieping Chen, Solomon Langermann, Stephen D. Miller,