کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6119427 | 1592311 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human T cells induce their own regulation through activation of B cells
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کلمات کلیدی
MFIPSSIL-10EAETregPC7Rheumatoid arthritis - آرتریتروماتوئیدexperimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیBreg - برگیAutoimmune disease - بیماری خودایمنیregulatory B cells - سلول های تنظیم کننده BT regulatory cell - سلول های تنظیم کننده ایRegulatory T cells - سلولهای تی تنظیمکنندهPrimary sjögren’s syndrome - سندرم اولیه SjögrenSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکmean fluorescence intensity - میانگین شدت فلورسانسT-cell response - پاسخ T-cell
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human T cells induce their own regulation through activation of B cells Human T cells induce their own regulation through activation of B cells](/preview/png/6119427.png)
چکیده انگلیسی
Regulatory functions for B lymphocytes have been reported in murine models of autoimmune diseases in which B-cell deficient mice were shown to exhibit exacerbated disease. The B cells responsible for the immune regulations were identified as a subpopulation of interleukin 10-secreting cells. However, the mechanism of induction and the characteristics of regulatory B cells in humans have been hardly studied. This study reports that regulation of T cell responses can be induced by B cells following CD40-dependent cognate interaction. T cell proliferation and cytokine production were differentially regulated. Thus, CD40-induced regulatory B cells partially inhibited T cell proliferation following CD40 interaction without requirement of soluble factor. In contrast, modulation of Th1 differentiation resulted from CD80- and CD86-dependent interactions and from IL-10 production. The suppressive effects were mediated by CD19highIgD+CD38highCD24highCD5high B cells and appeared to be indirect, through the induction of regulatory T cells as indicated by the appearance of Foxp3+CD4+CD25+T cells. These data suggest that activation signals from T cells initiate regulatory properties in B cells that modulate T cell responses involving regulatory T cells. Finally, studies in autoimmune patients revealed that regulation of T cell proliferation was defective in systemic lupus erythematosus but efficient in other diseases. Restoration of efficient B-cell regulatory activity could provide innovative B-cell based treatment of autoimmune diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 36, Issues 3â4, May 2011, Pages 228-238
Journal: Journal of Autoimmunity - Volume 36, Issues 3â4, May 2011, Pages 228-238
نویسندگان
Sébastien Lemoine, Ahsen Morva, Pierre Youinou, Christophe Jamin,