Tolerogenic dendritic cells and their role in transplantation

- Tolerogenic dendritic cells (DC) promote both central and peripheral tolerance.
- In rodents, donor or recipient-derived tolerogenic DC can promote long-term organ allograft survival.
- Peripheral blood DC with tolerogenic features have been detected in liver transplant patients with operational tolerance.
- Tolerogenic DC have been shown to promote antigen-specific T cell tolerance to model antigens in human volunteers.
- Pre-clinical trials in non-human primates will guide testing of tolerogenic DC therapy in human organ transplantation.