کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6125929 | 1221044 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis
ترجمه فارسی عنوان
مسیرهای تکمیل شده موجب ایجاد واکنش های بازسازی شده در سراسر فیتونوزیس می شود
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
HSCsC5aRC3aRRPEECMDAMPsCCl4MSCsASPHSPCs - HSPC هاiPE - IPEPHx - PHXAnaphylatoxins - آنافیلویتوکسین هاinflammation - التهاب( توروم) danger-associated molecular patterns - الگوهای مولکولی مرتبط با خطرRetinal pigmented epithelium - اپیتلیوم رنگدانه شبکیهInnate immunity - ایمنی ذاتیEMT - تکنسین فوریتهای پزشکیhematopoietic stem cells - سلول های بنیادی خونسازMesenchymal stem cells - سلول های بنیادی مزانشیمیExtracellular matrix - ماتریکس خارج سلولیComplement - متممMAC - مکPartial hepatectomy - هپاتکتومی جزئیacylation-stimulating protein - پروتئین تحریک کننده سکته مغزیmembrane attack complex - پیچیده حمله غشاءCarbon tetrachloride - کربن تتراکلریدepithelial-to-mesenchymal transition - گذار اپیتلیال به مزانشیمالC3a receptor - گیرنده C3aC5a receptor - گیرنده C5a
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Adult tissue plasticity, cell reprogramming, and organ regeneration are major challenges in the field of modern regenerative medicine. Devising strategies to increase the regenerative capacity of tissues holds great promise for dealing with donor organ shortages and low transplantation outcomes and also provides essential impetus to tissue bioengineering approaches for organ repair and replacement. The inherent ability of cells to reprogram their fate by switching into an embryonic-like, pluripotent progenitor state is an evolutionary vestige that in mammals has been retained mostly in fetal tissues and persists only in a few organs of the adult body. Tissue regeneration reflects the capacity of terminally differentiated cells to re-enter the cell cycle and proliferate in response to acute injury or environmental stress signals. In lower vertebrates, this regenerative capacity extends to several organs and remarkably culminates in precise tissue patterning, through cellular transdifferentiation and complex morphogenetic processes that can faithfully reconstruct entire body parts. Many lessons have been learned from robust regeneration models in amphibians such as the newt and axolotl. However, the dynamic interactions between the regenerating tissue, the surrounding stroma, and the host immune response, as it adapts to the actively proliferating tissue, remain ill-defined. The regenerating zone, through a sequence of distinct molecular events, adopts phenotypic plasticity and undergoes rigorous tissue remodeling that, in turn, evokes a significant inflammatory response. Complement is a primordial sentinel of the innate immune response that engages in multiple inflammatory cascades as it becomes activated during tissue injury and remodeling. In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals. Distinct complement-triggered pathways have been shown to modulate critical responses that promote tissue reprogramming, pattern formation, and regeneration across phylogenesis. This article will discuss the mechanistic insights underlying the crosstalk of complement with cytokine and growth factor signaling pathways that drive tissue regeneration and will provide a unified conceptual framework for considering complement modulation as a novel target for regenerative therapeutics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 25, Issue 1, February 2013, Pages 29-38
Journal: Seminars in Immunology - Volume 25, Issue 1, February 2013, Pages 29-38
نویسندگان
Dimitrios C. Mastellos, Robert A. DeAngelis, John D. Lambris,