کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6127808 | 1221412 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ketoconazole, a cytochrome P450 inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ketoconazole, a cytochrome P450 inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis Ketoconazole, a cytochrome P450 inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis](/preview/png/6127808.png)
چکیده انگلیسی
⺠Ketoconazole, an inhibitor of CYP3A4 enhanced the antimalarial potential of α/β arteether against Plasmodium falciparum 3D7. ⺠This combination has also produced the synergistic antimalarial activity against multi drug resistant malaria parasite Plasmodium yoelii nigeriensis in Swiss mice. ⺠Combined treatment cured 100% of infected mice as compared to the 60 and 0% with alone arteether and ketoconazole, respectively. ⺠Present study suggests that ketoconazole facilitate the favorable bioavailability of arteether by inhibiting CYP which is a metabolizing enzyme for arteether as well as through the moderate antiplasmodial action of ketoconazole itself.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 126, Issue 2, May 2013, Pages 150-155
Journal: Acta Tropica - Volume 126, Issue 2, May 2013, Pages 150-155
نویسندگان
Renu Tripathi, Amber Rizvi, Swaroop Kumar Pandey, Hemlata Dwivedi, J.K. Saxena,