کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6135819 | 1224904 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short communicationA regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/Treg cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and Treg-associated cytokines of children and adults. IL-6, IL-10 and TGF-β1 levels and Foxp3+ cell numbers were higher, but IL-1β, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion Treg instead of Th17 cell response to H. pylori-infection predominates in children.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 14, Issue 4, April 2012, Pages 341-347
Journal: Microbes and Infection - Volume 14, Issue 4, April 2012, Pages 341-347
نویسندگان
FabrÃcio Freire de Melo, Andreia Maria Camargos Rocha, Gifone Aguiar Rocha, Silvia Helena Sousa Pietra Pedroso, Sérgio de Assis Batista, Lúcia Porto Fonseca de Castro, Simone Diniz Carvalho, Paulo Fernando Souto Bittencourt, Celso Afonso de Oliveira,