کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139028 1594236 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8
چکیده انگلیسی
PDZD8 can bind the capsid proteins of different retroviruses, and transient knockdown of PDZD8 results in a decrease in the efficiency of an early, post-entry event in the retrovirus life cycle. Here we used the CRISPR-CAS9 system to create cell lines in which PDZD8 expression is stably eliminated. The PDZD8-knockout cell lines were infected by human immunodeficiency virus (HIV-1) and murine leukemia virus as efficiently as the parental PDZD8-expressing cells. These results indicate that PDZD8 is not absolutely necessary for HIV-1 infection and diminishes its attractiveness as a potential target for intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 481, July 2015, Pages 73-78
نویسندگان
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