کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6143180 1594383 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selected amino acid changes in HIV-1 subtype-C gp41 are associated with specific gp120V3 signatures in the regulation of co-receptor usage
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Selected amino acid changes in HIV-1 subtype-C gp41 are associated with specific gp120V3 signatures in the regulation of co-receptor usage
چکیده انگلیسی
► We analyzed genetic signatures in V3/gp41 underlying HIV-1 clade C co-receptor usage. ► Specific V3 signatures significantly associated with CCR5 or CXCR4 usage were found. ► Specific gp41 mutations significantly associated with R5 or X4 usage were found. ► Statistically significant correlations between V3-gp41 tropic signatures were found. ► Our findings fortify prior remarks that tropic-determinants may also reside in gp41.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 168, Issues 1–2, September 2012, Pages 73-83
نویسندگان
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