کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6227638 1276465 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T Lymphocytes and Vascular Inflammation Contribute to Stress-Dependent Hypertension
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
T Lymphocytes and Vascular Inflammation Contribute to Stress-Dependent Hypertension
چکیده انگلیسی

BackgroundPsychological stress is a significant risk factor for hypertension and also directly affects the immune system. We have previously reported that T lymphocytes are essential for development of hypertension and that the central nervous system contributes to peripheral T-lymphocyte activation and vascular inflammation in this disease; however, the role of T-cell activation in stress-related hypertension remains unclear.MethodsWild-type and T-cell-deficient (RAG-1−/−) mice were subjected to daily episodes of stress and blood pressure was measured. Circulating T-cell activation markers and vascular infiltration of immune cells were analyzed, as were stress hormone levels and gene expression changes in the brain. The effects angiotensin II infusion in the presence of chronic stress was also studied.ResultsRepeated daily stress contributed to acute elevations in blood pressure that were associated with increased activation of circulating T cells and increased vascular infiltration of T cells. Repeated stress increased blood pressure in wild-type but not RAG-1−/− mice. Adoptive transfer of T cells to RAG-1−/− mice restored blood pressure elevation in response to stress. Stress-related hypertension and vascular infiltration of T cells was markedly enhanced by angiotensin II. Moreover, angiotensin II-infused mice exposed to chronic stress exhibited greater blood pressure reactivity to an episode of acute stress.ConclusionsThese data demonstrate that stress-dependent hypertension triggers an inflammatory response that raises blood pressure at baseline and augments the hypertension caused by angiotensin II. These data provide insight as to how psychological stress contributes to hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 71, Issue 9, 1 May 2012, Pages 774-782
نویسندگان
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