کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6228290 1276521 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Functional Magnetic Resonance Imaging Study of Verbal Working Memory in Young People at Increased Familial Risk of Depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
A Functional Magnetic Resonance Imaging Study of Verbal Working Memory in Young People at Increased Familial Risk of Depression
چکیده انگلیسی

BackgroundPatients with depression show abnormalities in the neural circuitry supporting working memory. These abnormalities apparently persist into clinical remission, raising the possibility that they might be trait markers indicating vulnerability to depression.MethodsWe studied 17 young people who had a depressed parent but no personal history of depressive illness (FH) and 15 healthy control subjects with no family history of depression. Participants performed a verbal working memory task of varying cognitive load (n-back) while undergoing functional magnetic resonance imaging scanning. We used multiple regression analyses to assess overall capacity (1-, 2-, 3-back vs. 0-back) as well as linear and quadratic modulation of cognitive demand.ResultsPerformance accuracy and response latency did not differ between groups, and overall capacity was similar. However, for both linear and quadratic load response activity, FH participants showed greater activation in lateral occipital cortex, superior temporal cortex, and superior parietal cortex.ConclusionsOur data suggest that, as in depressed patients, maintenance of task performance in FH participants is associated with a significant increase in the load-response activity of the cortical regions involved in working memory. This neural abnormality could form part of the predisposition to develop depressive disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 67, Issue 5, 1 March 2010, Pages 471-477
نویسندگان
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