کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6228443 1276530 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Double Dissociation in the Roles of Serotonin and Mood in Healthy Subjects
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
A Double Dissociation in the Roles of Serotonin and Mood in Healthy Subjects
چکیده انگلیسی

BackgroundAffective disorders are associated with altered cognitive performance. However, the precise interaction between affect and cognition is unclear. The manipulation of serotonin (5-HT), a neurotransmitter implicated in affect, influences performance on “hot” cognitive tasks that require the processing of affective stimuli, but manipulation of affect via mood induction influences performance on “cold” cognitive tasks that do not involve affective stimuli. We attempted to disentangle the influence of affect on cognition by examining the effect of manipulating both serotonin (via acute tryptophan depletion [ATD]) and mood on established hot and cold cognitive tasks.MethodsIn a double blind, placebo-controlled crossover design, 33 healthy mood-induced (positive, negative, or neutral) subjects completed the (hot) affective go/no-go (AGNG) and (cold) one touch tower (OTT) following both placebo and ATD.ResultsMood influenced performance on the OTT but not AGNG; ATD influenced performance on the AGNG but not OTT.ConclusionsA double dissociation was demonstrated between the influence of ATD and mood on cognition, indicating that serotonin and mood are not closely linked. We hypothesize that this is due to the differences between emotions and moods and that aberrant cognition in affective disorders may be provoked through both bottom-up and top-down mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 65, Issue 1, 1 January 2009, Pages 89-92
نویسندگان
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