کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6244218 | 1609784 | 2012 | 6 صفحه PDF | دانلود رایگان |

ObjectivesTo compare vascular and parenchymal contrast enhancement in multidetector computed tomography of the liver using two contrast media with different iodine concentration (Iodixanol 320Â mgI/mL and Iomeprol 400Â mgI/mL) and similar viscosity, using fixed total iodine volume (40Â gI) and iodine delivery rate (1.6Â gI/s).Methods110 patients were prospectively randomized into two groups. Group A received 125Â mL of Iodixanol 320 and group B 100Â mL of Iomeprol 400.Attenuation values were measured at the level of the aorta, portal vein and liver parenchyma on unenhanced, arterial, portal and equilibrium phases. A non inferiority test was performed on the differences between the two groups. An independent reader evaluated image quality.ResultsThe equivalence of the two CM was demonstrated in all measurements. Higher, but not statistically significant, attenuation values were obtained with Iomeprol 400 in the aorta during the arterial phase (305.3Â HU versus 288.4Â HU; PÂ =Â 0.32) and with Iodixanol 320 in the liver parenchyma, during both portal (59.8Â HU versus 65.5Â HU; PÂ =Â 0.78) and equilibrium (40.4Â HU versus 41.8Â HU; PÂ =Â 0.55) phases.ConclusionsIodixanol 320 and Iomeprol 400 injected at the same iodine delivery rate (1.6Â gI/s) and total iodine load (40Â gI) did not provide statistically significant differences in liver parenchymal and vascular contrast enhancement.
Journal: European Journal of Radiology - Volume 81, Issue 11, November 2012, Pages 3096-3101