کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6244361 | 1609784 | 2012 | 8 صفحه PDF | دانلود رایگان |

PurposeTo investigate the correlation between the alterations of single-voxel 1H MRS and the histopathological characteristics of radiation brain injury following radiation.Materials and methodsTwenty-seven rabbits were randomized into nine groups to receive radiation with a single dose of 25Â Gy. The observation time points included a pre-radiation and 1, 2, 3, 4, 5, 6, 7, and 8Â wk following radiation. Each treatment group underwent conventional MRI and single-voxel 1H MRS, N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr) were observed over the region of interest, and the presence or absence of lactate (Lac) and lipid (Lip) was detected. Histological specimens of each group were obtained after image acquisition.ResultsThe values of Cho were significantly increased in the first 3Â wk, and decreased over the following 5Â wk after radiation. Levels of NAA showed a trend toward a decrease 5Â wk after radiation. The levels of Cr were not changed between before and after radiation. The Cho/NAA metabolic ratio was significantly increased in weeks 6, 7, and 8 following irradiation, compared to pre-radiation values. Vascular and glial injury appeared on 2Â wk after RT in the histology samples, until 4Â wk after RT, necrosis of the oligodendrocytes, neuronal degeneration and demyelination could be observed.ConclusionsMRS is sensitive to detect metabolic changes following radiation, and can be used in the early diagnosis of radiation brain injury.
Journal: European Journal of Radiology - Volume 81, Issue 11, November 2012, Pages 3496-3503