کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274083 | 1614816 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vasopressin indirectly excites dorsal raphe serotonin neurons through activation of the vasopressin1A receptor
ترجمه فارسی عنوان
وازوپرسین به طور غیر مستقیم باعث تحریک نورون های سروتونین ریف پشتی از طریق فعال شدن گیرنده وازپرسین می شود
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کلمات کلیدی
aCSFBNSTIPSCDNQXTphAVPTTXYFPventromedialV1aRPBSTEGTADICdorsomedialHEPESPBSimmunoreactive/immunoreactivity6,7-dinitroquinoxaline-2,3-dione - 6،7-dinitroquinoxaline-2،3-dioneBSA - BSAEPSC - EPSCoRarginine-vasopressin - آرژنین واسپرسینbovine serum albumin - آلبومین سرم گاوethylene glycol tetraacetic acid - اتیلن گلیکول تتراستیک اسیدhydroxyethyl piperazineethanesulfonic acid - اسید هیدروکسی تیلپیرازین اتان سولفونیکElectrophysiology - الکتروفیزیولوژیphosphate buffer - بافر فسفاتtetrodotoxin - تترو دوتوکسین analysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceinhibitory post-synaptic current - جریان فعلی مهارکننده سیناپسیexcitatory post-synaptic current - جریان پسا سیناپتی هیجان انگیزDorsal raphé - رفسنجی پشتیSerotonin - سروتونینAHP - فرایند تحلیل سلسلهمراتبیPhosphate buffered saline - فسفات بافر شورartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیbed nucleus of the stria terminalis - هسته تخت ترمینال های استریtryptophan hydroxylase - هیدروکسیلاز تریپتوفانvasopressin - وازوپرسینaction potential - پتانسیل عمل yellow fluorescent protein - پروتئین فلورسنت زردafter-hyperpolarization - پس از hyperpolarizationdifferential interference contrast - کنتراست تداخل دیفرانسیلglutamate - گلوتاماتV1a receptor - گیرنده V1a
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
The neuropeptide vasopressin (AVP; arginine-vasopressin) is produced in a handful of brain nuclei located in the hypothalamus and extended amygdala and is released both peripherally as a hormone and within the central nervous system as a neurotransmitter. Central projections have been associated with a number of functions including regulation of physiological homeostasis, control of circadian rhythms, and modulation of social behavior. The AVP neurons located in the bed nucleus of the stria terminalis and medial amygdala (i.e., extended amygdala) in particular have been associated with affiliative social behavior in multiple species. It was recently demonstrated that in the mouse AVP projections emanating from extended amygdala neurons innervate a number of forebrain and midbrain brain regions including the dorsal raphe nucleus (DR), the site of origin of most forebrain-projecting serotonin neurons. Based on the presence of AVP fibers in the DR, we hypothesized that AVP would alter the physiology of serotonin neurons via AVP 1A receptor (V1AR) activation. Using whole-cell electrophysiology techniques, we found that AVP increased the frequency and amplitude of excitatory post-synaptic currents (EPSCs) in serotonin neurons of male mice. The indirect stimulation of serotonin neurons was AMPA/kainate receptor dependent and blocked by the sodium channel blocker tetrodotoxin, suggesting an effect of AVP on glutamate neurons. Further, the increase in EPSC frequency induced by AVP was blocked by selective V1AR antagonists. Our data suggest that AVP had an excitatory influence on serotonin neurons. This work highlights a new target (i.e., V1AR) for manipulating serotonin neuron excitability. In light of our data, we propose that some of the diverse effects of AVP on physiology and behavior, including social behavior, may be due to activation of the DR serotonin system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 260, 28 February 2014, Pages 205-216
Journal: Neuroscience - Volume 260, 28 February 2014, Pages 205-216
نویسندگان
B.D. Rood, S.G. Beck,