The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups

▶ Maternal-separated rat pups showed depressive symptom and deceased memory function. ▶ Apoptosis in the hippocampus was increased in the maternal-separated rat pups. ▶ Tadalafil decreased the immobility time and increased memory function. ▶ Tadalafil improved depressive symptoms and ameliorated memory impairment. ▶ Tadalafil suppressed apoptosis in the maternal-separated rat pups.