کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6292060 1302511 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of immunity to Plasmodium: Implications from mouse models for blood stage malaria vaccine design
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Regulation of immunity to Plasmodium: Implications from mouse models for blood stage malaria vaccine design
چکیده انگلیسی
Malaria, a disease caused by the protozoan parasite Plasmodium, remains a serious healthcare problem in developing countries worldwide. While the host-parasite relationship in humans has been difficult to determine, the pliability of murine malaria models has enabled valuable contributions to the understanding of the pathogenesis of disease. Although no single model reflects precisely malaria infection of the human, different models collectively provide important information on the mechanisms of protective immunity and immunopathogenesis. This review summarizes progress towards understanding the broad spectrum of immune responsiveness to the blood stages of the malaria parasite during experimental infections in mice and highlights how examination of murine malarias sheds light on the factors involved in the modulation of vaccine-potentiated immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 126, Issue 3, November 2010, Pages 406-414
نویسندگان
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