کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6309616 | 1307453 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SO2 inhalation causes synaptic injury in rat hippocampus via its derivatives in vivo
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کلمات کلیدی
CREBSYPERKPSDPostsynaptic densitiescyclic AMP - AMP cycliccAMP - cAMPMAPK - MAPKIschemic injury - آسیب ایسکمیcognitive impairment - اختلال شناختیAlzheimer’s disease - بیماری آلزایمرlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP SO2 - دی اکسید گوگردSulfur dioxide - دی اکسید گوگردDIV - دیوdays in vitro - روز in vitroSynaptophysin - سیناپتوفیزینsynaptic vesicle - واژینال سیناپسیcAMP response element-binding protein - پروتئین واکنش القا کننده واکنش cAMPextracellular signal-regulated protein kinases - پروتئین کیناز سلول های تنظیم شده با سیگنالmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenSynaptic plasticity - پلاستیسیته سیناپسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
SO2 remains a common air pollutant, almost half of the world's population uses coal and biomass fuels for domestic energy. Limited evidence suggests that exposure to SO2 may be associated with neurotoxicity and increased risk of hospitalization and mortality of many brain disorders. However, our understanding of the mechanisms by which SO2 causes harmful insults on neurons remains elusive. To explore the molecular mechanism of SO2-induced neurotoxic effects in hippocampal neurons, we evaluated the synaptic plasticity in rat hippocampus after exposure to SO2 at various concentrations (3.5 and 7 mg mâ3, 6 h dâ1, for 90 d) in vivo, and in primary cultured hippocampal neurons (DIV7 and DIV14) after the treatment of SO2 derivatives in vitro. The results showed that SYP, PSD-95, NR-2B, p-ERK1/2 and p-CREB were consistently inhibited by SO2/SO2 derivatives in more mature hippocampal neurons in vivo and in vitro, while the effects were opposite in young hippocampal neurons. Our results indicated that in young neurons, SO2 exposure produced neuronal insult is similar to ischemic injury; while in more mature neurons, SO2 exposure induced synaptic dysfunctions might participate in cognitive impairment. The results implied that SO2 inhalation could cause different neuronal injury during brain development, and suggested that the molecular mechanisms might be involved in the changes of synaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 93, Issue 10, November 2013, Pages 2426-2432
Journal: Chemosphere - Volume 93, Issue 10, November 2013, Pages 2426-2432
نویسندگان
Yang Yun, Gaoyi Yao, Huifeng Yue, Lin Guo, Guohua Qin, Guangke Li, Nan Sang,