Evaluation of biotargeting and ecotoxicity of Co2+-containing nanoscale polymeric complex by applying multi-marker approach in bivalve mollusk Anodonta cygnea

► Bio-risks of cobalt(II)-containing nanomaterial and its compounds were compared. ► Biomarkers of stress and exposure in freshwater bivalve mollusk were utilized. ► Genotoxicity and oxidative stress were common responses. ► Complexing prevented bio-toxic effects of separate compounds. ► Metallothionein was the main distinguishing biomarker of specific effect.