Chlorpyrifos acute exposure induces hyperglycemia and hyperlipidemia in rats

► Hyperglycemic and hyperlipidemic effects of chlorpyrifos in rats were investigated. ► A single chlorpyrifos administration caused hyperglycemia and hyperlipidemia in rats. ► Chlorpyrifos increased corticosterone levels and gluconeogenic enzyme activities. ► Gluconeogenesis pathway is involved in the hyperglycemic effect of chlorpyrifos. ► Chlorpyrifos increased triglycerides and low-density lipoprotein-cholesterol levels.