Extracts from hardwood trees used in commercial paper mills contain biologically active neurochemical disruptors

► Neuroactive chemicals in effluent are potentially phytochemicals in wood. ► Extracts of hardwoods bound to receptors in the neuroendocrine reproductive axis. ► Extracts altered activities of key enzymes in the neuroendocrine reproductive axis. ► Butternut wood extracts and juglone are important leads as reproductive inhibitors. ► These neuroendocrine data are also of pharmacological importance.