Biofabrication of polyphenols stabilized reduced graphene oxide and its anti-tuberculosis activity

- Eco friendly synthetic approach for graphene synthesis using C. verum extract
- Capping of graphene sheets with C. verum extract polyphenols
- Effective growth inhibition of M. tuberculosis H37Ra with synthesized graphene

A facile one step eco-friendly method for the reduction graphene oxide by Cinnamomum verum (C. verum) bark extract is reported in this work. This approach avoids the utilization of hazardous chemical reagents. The characterization results of various spectroscopic and microscopic techniques for the prepared graphene oxide (GO) and reduced graphene oxide (RGO) afford a strong indication of the removal of oxygen functionalities of GO after reduction and following stabilization by the oxidised polyphenols. Fourier transform infrared spectral results showed the capping of oxidised polyphenols onto the surface of reduced graphene oxide which further prevent their aggregation. Additionally, the prepared graphene nanosheets were tested for their antituberculosis activity against standard strain such as M. tuberculosis H37Ra. The obtained results suggested that the synthesized graphene acts as an effective growth inhibitors against M. tuberculosis H37Ra making it applicable for targeted drug delivery by combining with other chemical drugs as a therapeutic index.