Mutually exclusive binding of APPLPH to BAR domain and Reptin regulates β-catenin dependent transcriptional events

- We study the structural basis of APPL and Reptin binding in context with APPL1/APPL2 dimerization.
- We perform a detailed in silico analysis using the knowledge of APPL1/2 heterodimerization and infer that binding of APPLPH to BAR domain and Reptin is mutually exclusive which may facilitate Reptin in nucleocytoplasmic shuttling.
- We report new insights into the distinctive characterization of APPL-β-catenin-Reptin-HDACs ternary complex in terms of target gene regulation and transcriptional mechanisms.