Keywords: دامنه PH; Phospholipid; Phosphoinositide; Membrane; PH domain; Phospholipase C; PX domain; FYVE domain; Fluorescent imaging; TIRF microscopy; BRET analysis; FRET analysis; Confocal microscopy;
مقالات ISI دامنه PH (ترجمه نشده)
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Keywords: دامنه PH; Synaptic plasticity; Neuromodulation; Phosphoinositides; AMPA receptors; VSPs; Fluorescence imaging; G-protein-coupled receptor; PH domain; Ion channel regulation; LTP; LTD
Keywords: دامنه PH; AA; arachidonic acid; Aβ; fibrillar β-amyloid; ACC; acetyl-CoA carboxylase; Akt; protein kinase B; APP; amyloid precursor protein; ASAH2; neutral ceramidase; BA; benzyl alcohol; BBB; blood-brain-barrier; BMI; body mass index; BPM; bis(monoacylglycero)
Keywords: دامنه PH; C2 domain; FYVE domain; Lipid binding; Membrane binding; Phosphoinsoitide; PI(3)P; PI(4,5)P2; PI(3,4,5)P3; PH domain; Peripheral protein.ANTH, AP180 amino-terminal homology; BAR, Bin amphiphysin Rvs (BAR); C2, protein kinase C conserved 2; ENTH, epsin ami
Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1
Keywords: دامنه PH; Fission yeast; Golgi; pik1+; PI(4)P; PH domain; Telomere;
Direct regulation of p190RhoGEF by activated Rho and Rac GTPases
Keywords: دامنه PH; RhoGEF; Rho guanine nucleotide exchange factors; RhoGAP; GTPase-activating proteins; DH; Dbl homology; PH; pleckstrin homology; PRG; PDZRhoGEF; TEV; Tobacco Etch Virus; His6; hexahistidine peptide; GST; glutathione S-transferase; ITC; isothermal titration
Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding
Keywords: دامنه PH; GEF-H1; PH domain; Crystal structure; Phosphoinositide;
Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells
Keywords: دامنه PH; Chediak-Higashi syndrome; lysosomal trafficking regulator; natural killer cell; cytotoxicity; cytotoxic lymphocyte; lysosomes; lytic granules; exocytosis; immune deficiency; ARM/HEAT domain; Armadillo/huntingtin, elongation factor 3, protein phosphatase 2
Immunoreceptors on neutrophils
Keywords: دامنه PH; ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch
Keywords: دامنه PH; Crk; CT10 regulator of kinase; CRKL; Crk-like protein; ERK; extracellular signal regulated kinase; FCS; foetal calf serum; Gab1; Grb2-associated binder 1; Grb2; growth factor receptor bound protein 2; IL-6; interleukin-6; JAK; Janus kinase; HEK; human emb
PIPs in neurological diseases
Keywords: دامنه PH; Aβ; amyloid β protein; CMT; Charcot-Marie-Tooth; GPCR; G protein-coupled receptor; PICALM; phosphatidylinositol binding clathrin assembly protein; PIPs; phosphoinositides, PI3K, phosphoinositide 3-kinase; PI4K; phosphatidylinositol 4-kinase; PLC; ph
Tracing the evolution of FERM domain of Kindlins
Keywords: دامنه PH; FERM domain; Kindlins; Protein domain evolution; Evolutionary trace analysis; Focal adhesions; PH domain
BDNF-induced local protein synthesis and synaptic plasticity
Keywords: دامنه PH; Brain-derived neurotrophic factor (BDNF); Synaptic plasticity; Long-term potentiation (LTP); Translation; RNA transport; ADF; actin-depolymerizing factor; A2RE; heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element; Arc; activity-regulated c
CKIP-1: A scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions
Keywords: دامنه PH; ATM; ataxia-telangiectasia mutated; CHX; cycloheximide; CK2; casein kinase 2; CKIP-1; casein kinase 2 interacting protein-1; CP; capping protein; IFN; interferon; IFP35; IFN-induced protein 35kDa; LZ; leucine zipper; Nmi; N-Myc interacting protein; PH; pl
Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism
Keywords: دامنه PH; Feedback control; Sphingomyelin synthase 1; Sphingomyelin synthesis; Cer; ceramide; CHO Cells; Chinese hamster ovary cells; DAG; diacylglycerol; ER; endoplasmic Reticulum; IFT; implicit function theorem; PC; phosphatidylcholine; PH Domain; pleckstrin homo
Mutually exclusive binding of APPLPH to BAR domain and Reptin regulates β-catenin dependent transcriptional events
Keywords: دامنه PH; Reptin; APPL; PH domain; BAR domain; β-Catenin; Molecular docking;
EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis
Keywords: دامنه PH; Arf6; Cleavage furrow; Cytokinesis; EFA6; Flemming body; PH domain
Associations between the Rho kinase-1 catalytic and PH domain regulatory unit
Keywords: دامنه PH; Rho-associated kinase; ROCK; Docking; PH domain
Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks
Keywords: دامنه PH; Abl; Abelson tyrosine-protein kinase 1; ADAP1; arf-GAP with dual PH domain-containing protein 1; AFM; atomic force microscopy; cAMP; cyclic adenosine monophosphate; ApoER2; apolipoprotein E receptor 2; BCAR1; breast cancer anti-estrogen resistance 1; p130
Second basic pockets contribute to the localization of PX domains by binding to phosphatidic acid
Keywords: دامنه PH; class III PI3K; class III phosphatidylinositol 3-kinase (E.C.2.7.1.137); DGK; diacylglycerol kinase (E.C.2.7.1.107); DMEM; Dulbecco's modified Eagle's Medium; EEA1; early endosomal antigen 1; ENTH; epsin N-terminal homologue; FYVE; Fab1p/YOTP/Vac1p/EE
Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors
Keywords: دامنه PH; ATP; adenosine triphosphate; Boc; tert-butoxycarbonyl; CDI; 1,1â²-carbonyldiimidazole; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; DNPH; O-(2,4-dinitrophenyl)hydroxylamine; EDTA; ethylenediaminetetraacetic acid; ip; intraperitoneal; MEM; minimu
Development of sulfonamide AKT PH domain inhibitors
Keywords: دامنه PH; AKT; protein kinase B; β-ARK; β-adrenergic receptor kinase; CREB; cAMP response element-binding; DMEM; Dulbecco's modified Eagle medium; DPIEL; deoxyphosphatidylinositol ether lipid; ELISA; enzyme-linked immunosorbent assay; ESI; electrospray ionizati
Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane
Keywords: دامنه PH; PLC; phospholipase C; Ins(1,4,5)P3; myo-inositol 1,4,5-trisphosphate; DAG; diacylglycerol; PI(4,5)P2; phospatidylinositol 4,5-bisphosphate; PH domain; pleckstrin homology domain; Myo6; myosin VI; PCR; polymerase chain reaction; CBD; cargo binding domain;
The RasGrf family of mammalian guanine nucleotide exchange factors
Keywords: دامنه PH; GEFs; guanine nucleotide exchange factors; NMDA; N-methyl-d-aspartate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; CNS; Central Nervous System; DMD; differentially methylated domain; CTCF; CCCTC-binding protein; CDB; cyclin destruction b
Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways
Keywords: دامنه PH; PIs; phosphoinositides; PtdIns5P; phosphatidylinositol 5-phosphate; IL-2; interleukin II; TCR; T-cell receptor; Cell signaling; Phosphoinositide; Phosphatidylinositol 5-phosphate; PH domain; T lymphocyte; T-cell activation;
ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences
Keywords: دامنه PH; PH; Pleckstrin Homology; PI3K; Phosphatidyl 3OH Kinase; PtdIns(3,4,5)P3; Phosphatidylinositol-(3,4,5)-trisphosphate; PtdIns(3,4)P2; Phosphatidylinositol-(3,4)-bisphosphate; GAP; GTPase Activating Protein; SAM; Sterile Alpha Motif; SHIP2; SH2-containing in
Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate
Keywords: دامنه PH; IGF-I; insulin-like growth factor I; siRNA; small interfering RNA; IGF-IR; IGF-I receptor; PI 3-kinase; phosphatidylinositol 3-kinase; PIP3; phosphatidylinositol 3,4,5-triphosphate; F-actin; actin filament; CLIP; cytoplasmic linker protein; CLAPS; CLIP-as
The PH-PxxP domain of RalGPS2 promotes PC12 cells differentiation acting as a dominant negative for RalA GTPase activation
Keywords: دامنه PH; Signal transduction; Guanine nucleotide exchange factor; MAPK; PH domain; GFP fusion proteins; Actin;
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
Keywords: دامنه PH; PLC; phospholipase C; PI(4,5)P2; phosphatidylinositol 4,5-bisphosphate; PI(3,4,5)P2; phosphatidylinositol 3,4,5-bisphosphate; Ins(1,4,5)P3; inositol 1,4,5-trisphosphate; DAG; diacylglycerol; PKC; protein kinase C; PI3K; phosphatidylinositol 3-kinase; PDGF
Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy
Keywords: دامنه PH; PI3K; Phosphoinositide; PH domain; Confocal microscopy; Fluorescence; Colorectal cancer
Regulation of ROCKII by localization to membrane compartments and binding to DynaminI
Keywords: دامنه PH; ROCK; PH domain; Dynamin; Membrane; Subcellular localization
A single circularly permuted GFP sensor for inositol-1,3,4,5-tetrakisphosphate based on a split PH domain
Keywords: دامنه PH; Biosensor; PH domain; Structure-based design; Green fluorescent protein; Inositol polyphosphates
Grb2 associated binder 2 couples B-cell receptor to cell survival
Keywords: دامنه PH; B-cell; Signaling; Gab2 adaptor/scaffolding protein; Phosphorylation; PH domain; Survival;
CERT-mediated trafficking of ceramide
Keywords: دامنه PH; PH domain; START domain; FFAT motif; Membrane contact site
Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-δ1
Keywords: دامنه PH; Phospholipase C-δ1; PH domain; Solid state NMR; Membrane curvature; Cellular signal transduction
Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion
Keywords: دامنه PH; Adhesion; AKT isoform; AKT1; AKT2; Pressure; PH domain; Hinge region
Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule
Keywords: دامنه PH; RNA granule; Mitochondria; PH domain; Tyrosine phosphorylation; Cytochrome c;
Physiological functions of phospholipase C δ-type
Keywords: دامنه PH; PLC; phospholipase C; Ins(1,4,5)P3; myo-inositol 1,4,5-trisphosphate; DAG; diacylglycerol; PI(4,5)P2; phospatidylinositol 4,5-bisphosphate; PH domain; pleckstrin homology domain; SH domain; src homology domain; RA domain; Ras-associating domain; RasGEF; R
PH domain-mediated membrane targeting of Asef
Keywords: دامنه PH; APC; Asef; PH domain; GEF; G-protein; E-cadherin
Phospholipid binding properties and functional characterization of a sea urchin phospholipase Cδ in urchin and mouse eggs
Keywords: دامنه PH; Calcium; Phospholipase C; PLCδ; PH domain; Egg; Embryo; Sea urchin
Structural determinants of LL5β subcellular localisation and association with filamin C
Keywords: دامنه PH; PI3K, phosphoinositide 3-OH kinase; PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PH, pleckstrin homology; PDGF, platelet derived growth factor.LL5β; filamin; PI3K; PH domain; Cytoskeleton
CERT and intracellular trafficking of ceramide
Keywords: دامنه PH; PH domain; START domain; FFAT motif; Membrane contact sites
Stimulation of phospholipase Cβ by membrane interactions, interdomain movement, and G protein binding — How many ways can you activate an enzyme?
Keywords: دامنه PH; PLC; Gβγ; PH domain
Regulation of phosphoinositide 3-kinase signaling by oxidants: Hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins
Keywords: دامنه PH; Phosphoinositide 3-kinase; Lymphocyte; Immunoreceptor; Oxidant; Peroxide; PH domain; TAPP2; PTEN;
Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells
Keywords: دامنه PH; Macropinocytosis; Ruffling; Phosphoinositides; Phosphoinositide 3-kinase; PH domain; Actin cytoskeleton; Signal transduction; Imaging
Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase
Keywords: دامنه PH; RalGPS2; GEF; RalA; PH domain; Actin
Determining selectivity of phosphoinositide-binding domains
Keywords: دامنه PH; Phosphoinositide; PH domain; Surface plasmon resonance; Centrifugation; Lipid binding; Vesicle; Membrane; Inositol
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation
Keywords: دامنه PH; Lymphocyte; Signal transduction; Adaptor; PH domain; Phosphatidylinositol 3-kinase;
Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants
Keywords: دامنه PH; DPER; dilated peripheral ER; EM; electron microscopy; ER; endoplasmic reticulum; FFAT motif; two phenylalanines in an acidic tract motif; IF; immunofluorescence; OR; OSBP-related; 25OH; 25-hydroxycholesterol; ORP; OSBP-related protein; OSBP; oxysterol bin