کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2019218 | 1068563 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
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کلمات کلیدی
PDGFSrc Homology domainRasGEFKO micePI3KPDZPKCPLCtPAEGFNFATinositol 1,4,5-trisphosphate - inositol 1،4،5-trisphosphateIns(1,4,5)P3 - Ins (1،4،5) P3PI(4,5)P2 - PI (4،5) P2Knock out mice - از دست دادن موش هاPH domain - دامنه PHPleckstrin homology domain - دامنه هماهنگی Pleckstrindiacylglycerol - دیسیل گلیسیرینDAG - روزepidermal growth factor - عامل رشد اپیدرمیNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهplatelet-derived growth factor - فاکتور رشد حاصل از پلاکتPhosphatidylinositol 3-kinase - فسفاتیدیلینواستیل 3-کینازphosphatidylinositol 4,5-bisphosphate - فسفاتیدیلینوزیتول 4،5-بیسفسفاتPhosphoinositides - فسفوئینوزیت هاphospholipase C - فسفولیپاز CZona pellucida - منطقه کوچکProtein kinase C - پروتئین کیناز سیTRP channel - کانال TRPTransient receptor potential channel - کانال بالقوه گیرنده گذراCalcium - کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance](/preview/png/2019218.png)
چکیده انگلیسی
Spatial and temporal activation of phosphoinositide turnover enables eukaryotic cells to perform various functions such as cell proliferation/differentiation, fertilization, neuronal functions, and cell motility. In this system, phospholipase C (PLC) is a key enzyme, which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) into two second messengers, inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and diacylglycerol (DAG). Ins(1,4,5)P3 triggers the release of calcium from intracellular stores, and DAG mediates the activation of protein kinase C (PKC). In parallel, PI(4,5)P2 also directly regulates a variety of cellular functions, including cytoskeletal remodeling, cytokinesis, phagocytosis, membrane dynamics, and channel activity, in addition to its role as a substrate for PLC and phosphatidylinositol 3-kinase (PI3K), which generates PI(3,4,5)P3. An imbalance of these phosphoinositides contributes to the pathogeneses of various human diseases. Therefore, strict regulation of the levels of PI(4,5)P2 and PI(3,4,5)P3 by PLC or other interconverting enzymes is necessary for cellular functions. In this review, we focus on the roles of PLC as a calcium-regulating enzyme and as a modulator of the phosphoinositide balance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 49, Issue 4, October 2010, Pages 429-437
Journal: Progress in Lipid Research - Volume 49, Issue 4, October 2010, Pages 429-437
نویسندگان
Kiyoko Fukami, Shunichi Inanobe, Kaori Kanemaru, Yoshikazu Nakamura,