Rh catalyzed multicomponent tandem and one-pot reactions under hydroformylation conditions

• Last 10 years of reasearch in the field of Rh catalyzed tandem reactions under hydroformylation conditions are covered.
• New catalysis concepts and new ligand designs are presented.
• Selectivity and activity of Rh complexes in different tandem processes.
• Organocatalysis in combination with metal catalysis: new emerging field.
• Pharmaceuticaly relevant compounds, alkaloid privileged structures: tandem catalysis as a cost efficient alternative.

The hydroformylation reaction represents one of the most important metal catalyzed bulk chemical manufacturing processes today. However, tremendous progress towards more complex molecules using tandem hydroformylation has been achieved during the past decade. Different approaches towards indoles and other nitrogen containing heterocycles, alkaloids, and other biologically active compounds are steadily turning hydroformylation into one of the methods to be considered even in the complex syntheses of natural products and other fine chemicals. The application of organocatalyzed processes coupled with formation of aldehydes through hydroformylation reaction in the synthesis of enantioenriched fine chemicals is another turning point in the application of this reaction. Vast number of other new reaction sequences under hydroformylation conditions have been developed turning tandem and one pot sequences under hydroformylation conditions into a method of choice for organic chemistry and catalysis practitioners.

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