کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6490145 1416963 2018 45 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and testing of a highly conserved human rotavirus VP8* immunogenic peptide with potential for vaccine development
ترجمه فارسی عنوان
طراحی و آزمایش پپتید ایمونوژنیک روتاویروس انحصاری انسانی بسیار محافظت شده با پتانسیل توسعه واکسن
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Success of such a vaccine would depend to a large extent on the antigenic peptide to be used in antibody production. The non-glycosylated protein VP4 on the surface capsid of the virus is important in rota viral immunogenicity and the major antigenic site(s) responsible for neutralization of the virus via VP4 is in the VP8* subunit of VP4. It is necessary that the peptide should be very specific and a peptide sequence which would stimulate both the T and B immunogenic cells would provide maximum protection against the virus. Advanced computational techniques and existing databases of sequences of the VP4 protein of rotavirus help in identification of such specific sequences. Using an in silico approach we have identified a highly conserved VP8* subunit of the VP4 surface protein of rotavirus which shows both T and B cell processivity and is also non-allergenic. This sub-unit could be used in in vivo models for induction of antibodies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biotechnology - Volume 281, 10 September 2018, Pages 48-60
نویسندگان
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