کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6490584 43372 2016 35 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel approach for emerging and antibiotic resistant infections: Innate defense regulators as an agnostic therapy
ترجمه فارسی عنوان
یک رویکرد جدید برای عفونت های مقاوم در برابر آنتی بیوتیک و آنتی بیوتیک: تنظیم کننده های ضد انعقاد به عنوان یک درمان عقلانی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
The studies reported here show that the lead clinical IDR, SGX94, has broad-spectrum activity against Gram-negative and Gram-positive bacterial infections caused by intracellular or extracellular bacteria and also complements the actions of standard of care antibiotics. Based on in vivo and primary cell culture studies, this activity is shown to result from the primary action of SGX94 on tissue-resident cells and subsequent secondary signaling to activate myeloid-derived cells, resulting in enhanced bacterial clearance and increased survival. Data from non-clinical and clinical studies also show that SGX94 treatment modulates pro-inflammatory and anti-inflammatory cytokine levels, thereby mitigating the deleterious inflammatory consequences of innate immune activation. Since they act through host pathways to provide both broad-spectrum anti-infective capability as well as control of inflammation, IDRs are unlikely to be impacted by resistance mechanisms and offer potential clinical advantages in the fight against emerging and antibiotic resistant bacterial infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biotechnology - Volume 226, 20 May 2016, Pages 24-34
نویسندگان
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