کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6493342 | 1418053 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced graphene oxide coated Cu2âxSe nanoparticles for targeted chemo-photothermal therapy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reduced graphene oxide coated Cu2âxSe nanoparticles for targeted chemo-photothermal therapy Reduced graphene oxide coated Cu2âxSe nanoparticles for targeted chemo-photothermal therapy](/preview/png/6493342.png)
چکیده انگلیسی
Recently, copper chalcogenide semiconductors have been reported as new near-infrared (NIR) photothermal agents. However, it is difficult to modify them with recognition molecules, and their photothermal conversion efficiencies are relatively low, making it difficult to achieve the targeted photothermal ablation of cancer cells with a high efficiency. In this study, reduced graphene oxide (rGO) was first coated on the surface of Cu2-xSe nanoparticles (NPs) to provide abundant functional groups for the next modification and to increase the photothermal conversion efficiency. Then, doxorubicin (DOX) was loaded and folic acid (FA) molecules were covalently linked onto the surface of Cu2âxSe/rGO nanocomposites. The formed DOX@Cu2âxSe@rGO-FA nanocomposites were successfully used as chemo-photothermal agents for the targeted killing of cancer cells by utilizing the recognition ability of FA, chemotherapy effect of DOX and photothermal effects of rGO and Cu2âxSe NPs. Under the 980-nm NIR laser irradiation, the nanocomposites showed significantly enhanced chemo-photothermal therapy effect, which can be potentially applied in the nanomedicine field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 180, March 2018, Pages 9-16
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 180, March 2018, Pages 9-16
نویسندگان
Shu Jun Zhen, Ting Ting Wang, Yu Xin Liu, Zhu Lian Wu, Hong Yan Zou, Cheng Zhi Huang,