کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6494832 | 1418372 | 2018 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Economic feasibility and environmental impact of synthetic spider silk production from escherichia coli
ترجمه فارسی عنوان
امکان سنجی اقتصادی و اثرات زیست محیطی تولید ابریشم عنکبوت مصنوعی از اشرشیا کولی
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کلمات کلیدی
DCWDCFRORMajor ampullate silkGHGsMASPLCIHPHIPTGE. coliBECTOCCEPCI - CEPCTff - TFFTechno-economic assessment - ارزیابی فنی و اقتصادیLifecycle assessment - ارزیابی چرخه حیاتLCA - ارزیابی چرخه حیاتLife Cycle Assessment - ارزیابی چرخه عمر یا چرخه حیاتEscherichia coli - اشریشیا کُلیGreenhouse gas emissions - انتشار گازهای گلخانه ایTechno-economic analysis - تجزیه و تحلیل تکنولوژیکی و اقتصادیTransgenic - تراریختهTangential flow filtration - تصفیه جریان مماسیChemical Engineering Plant Cost Index - شاخص هزینه کارخانه شیمیاییLife Cycle Inventory - موجودی چرخه زندگیHigh pressure homogenization - همگن سازی فشار بالاdry cell weight - وزن سلول خشکTEA - چایoptical density - چگالی نوریGreenhouse gases - گازهای گلخانه ای
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Major ampullate spider silk represents a promising protein-based biomaterial with diverse commercial potential ranging from textiles to medical devices due to its excellent physical and thermal properties. Recent advancements in synthetic biology have facilitated the development of recombinant spider silk proteins from Escherichia coli (E. coli). This study specifically investigates the economic feasibility and environmental impact of synthetic spider silk manufacturing. Pilot scale data was used to validate an engineering process model that includes all of the required sub-processing steps for synthetic fiber manufacture: production, harvesting, purification, drying, and spinning. Modeling was constructed modularly to support assessment of alternative downstream processing technologies. The techno-economic analysis indicates a minimum sale price from pioneer and optimized E. coli plants of $761â¯kgâ1 and $23â¯kgâ1 with greenhouse gas emissions of 572â¯kg CO2-eq. kgâ1 and 55â¯kg CO2-eq. kgâ1, respectively. Elevated costs and emissions from the pioneer plant can be directly tied to the high material consumption and low protein yield. Decreased production costs associated with the optimized plant includes improved protein yield, process optimization, and an Nth plant assumption. Discussion focuses on the commercial potential of spider silk, the production performance requirements for commercialization, and the impact of alternative technologies on the system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: New Biotechnology - Volume 42, 25 May 2018, Pages 12-18
Journal: New Biotechnology - Volume 42, 25 May 2018, Pages 12-18
نویسندگان
Alan M. Edlund, Justin Jones, Randolph Lewis, Jason C. Quinn,