Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of α,α-dicyanoolefins to nitroalkenes

- The first example of lipase-catalyzed direct vinylogous Michael addition reactions.
- Lipozyme® showed good activities and excellent diastereoselectivities under optimized conditions.
- This biocatalytic processes were economical and green for further applications.
- Docking studies were performed to further illuminate the differences between various enzymes and substrates.