Kinetic resolution of (R,S)-1,2-isopropylidene glycerol (solketal) ester derivatives by lipases

▶ We studied the resolution of racemic solketal (IPG) ester derivatives by lipases. ▶ IPG octanoate was found to be a better substrate than acetate counterpart. ▶ Among several lipases, Amano AK led to the best selectivities (E up to 200).