Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

The PLA was found to be the key variable in optimizing the nanoparticle preparation, producing spherical nanoparticles with a thymol encapsulation efficiency of 60.3 ± 8%. These nanoparticles showed a high storage stability at several pHs and improved antimicrobial properties in comparison with the non-encapsulated thymol.