کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6791327 | 1432685 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Randomized trial of omega-3 for autism spectrum disorders: Effect on cell membrane composition and behavior
ترجمه فارسی عنوان
محاکمه تصادفی امگا 3 برای اختلالات طیف اوتیسم: تأثیر بر ترکیب و رفتار غشای سلولی
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کلمات کلیدی
آزمایشهای تصادفی کنترل شده، اختلال اسپکتروم اوتیسم، اسیدهای چرب امگا 3، اسیدهای چرب غیر اشباع، بیومارکرها،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
A high Ï6/Ï3 ratio [fatty acid (FA) index] in the cell membrane has been associated with inadequate brain development. It has started to be used as a biomarker of treatment efficacy in human diseases. The aim of this study was to investigate if omega-3 supplementation improves erythrocyte membrane Ï6/Ï3, plasma antioxidant status (TAS) and autistic behaviors. A randomized, crossover, placebo-controlled study was designed to investigate the effect of 8 weeks of supplementation with Ï3 (962Â mg/d and 1155Â mg/d for children and adolescents, respectively). Sixty-eight children and adolescents with Autism Spectrum Disorders (ASD) completed the full protocol. Primary outcome measures were erythrocyte membrane FA composition and TAS. Secondary outcome measures were Social Responsiveness Scale and Clinical Global Impression-Severity. Treatment with Ï3 improved the erythrocyte membrane Ï6/Ï3 ratio (treatment effect p<0.008, d=0.66; within subjects effect p<0.007, d=0.5) without changing TAS. There was a within subjects significant improvement in Social Motivation and Social Communication subscales scores, with a moderate to large effect size (p=0.004, d=0.73 and p=0.025, d=0.79 respectively), but no treatment effect (treatment-placebo order). Carryover effects cannot be discarded as responsible for the results in behavioral measures. In conclusion, supplementation with Ï3 FA might be studied as an add-on to behavioral therapies in ASD. Optimal duration of treatment requires further investigation. With regard to side effects, the effect of this supplementation on the lipid profile needs monitoring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 27, Issue 12, December 2017, Pages 1319-1330
Journal: European Neuropsychopharmacology - Volume 27, Issue 12, December 2017, Pages 1319-1330
نویسندگان
Mara Parellada, Cloe Llorente, Rosa Calvo, Silvia Gutierrez, Luisa Lázaro, Montserrat Graell, Maria Guisasola, Maria Luisa Dorado, Leticia Boada, Jose Romo, Elena Dulin, Inmaculada Sanz, Celso Arango, Carmen Moreno,