کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6822708 | 548431 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n = 36), unaffected siblings (SB, n = 36) and healthy controls (HC, n = 47). SZ had shorter TL compared to HC, but no difference was found in SB comparing to SZ. These findings indicate that a pathological accelerated aging profile could be present in the course of SZ and further studies are needed to confirm TL as potential endophenotype, especially in at risk populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 174, Issues 1â3, July 2016, Pages 39-42
Journal: Schizophrenia Research - Volume 174, Issues 1â3, July 2016, Pages 39-42
نویسندگان
Leticia Sanguinetti Czepielewski, Raffael Massuda, Bruna Panizzutti, Eduarda Dias da Rosa, David de Lucena, Danielle Macêdo, Lucas Kich Grun, Florencia MarÃa Barbé-Tuana, Clarissa Severino Gama,