کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6824016 | 548461 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Creativity and positive symptoms in schizophrenia revisited: Structural connectivity analysis with diffusion tensor imaging
ترجمه فارسی عنوان
خلاقیت و علائم مثبت در بیماری اسکیزوفرنی: بازنگری در ارتباطات ساختاری با تصویربرداری از تانسور انتشار
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کلمات کلیدی
PDIATRTCTTBSSDTICategory fluency testTFCELetter Fluency TestSCIDPANSSCorpus callosumtract-based spatial statistics - آمار مکانی مبتنی بر تراکمExecutive dysfunction - اختلال اجراییSchizophrenia - اسکیزوفرنی یا شیزوفرنیthreshold-free cluster enhancement - افزایش خوشه ای آستانه ایAnterior thalamic radiation - تابش تلامام قدامیdiffusion tensor imaging - تصویربرداری تانسور انتشارJART - جارتPhonological fluency - روانشناسی صوریPositive and Negative Symptom Scale - مقیاس علائم مثبت و منفیfractional anisotropy - ناپیوستگی کسریHaloperidol - هالوپریدولDelusions - هذیانhealthy control - کنترل سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Both creativity and schizotypy are suggested to be manifestations of the hyperactivation of unusual or remote concepts/words. However, the results of studies on creativity in schizophrenia are diverse, possibly due to the multifaceted aspects of creativity and difficulties of differentiating adaptive creativity from pathological schizotypy/positive symptoms. To date, there have been no detailed studies comprehensively investigating creativity, positive symptoms including delusions, and their neural bases in schizophrenia. In this study, we investigated 43 schizophrenia and 36 healthy participants using diffusion tensor imaging. We used idea, design, and verbal (semantic and phonological) fluency tests as creativity scores and Peters Delusions Inventory as delusion scores. Subsequently, we investigated group differences in every psychological score, correlations between fluency and delusions, and relationships between these scores and white matter integrity using tract-based spatial statistics (TBSS). In schizophrenia, idea and verbal fluency were significantly lower in general, and delusion score was higher than in healthy controls, whereas there were no group differences in design fluency. We also found positive correlation between phonological fluency and delusions in schizophrenia. By correlation analyses using TBSS, we found that the anterior part of corpus callosum was the substantially overlapped area, negatively correlated with both phonological fluency and delusion severity. Our results suggest that the anterior interhemispheric dysconnectivity might be associated with executive dysfunction, and disinhibited automatic spreading activation in the semantic network was manifested as uncontrollable phonological fluency or delusions. This dysconnectivity could be one possible neural basis that differentiates pathological positive symptoms from adaptive creativity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 164, Issues 1â3, May 2015, Pages 221-226
Journal: Schizophrenia Research - Volume 164, Issues 1â3, May 2015, Pages 221-226
نویسندگان
Shuraku Son, Manabu Kubota, Jun Miyata, Hidenao Fukuyama, Toshihiko Aso, Shin-ichi Urayama, Toshiya Murai, Hidehiko Takahashi,