کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6827603 548534 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of serum BDNF levels with hippocampal volumes in first psychotic episode drug-naive schizophrenic patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Association of serum BDNF levels with hippocampal volumes in first psychotic episode drug-naive schizophrenic patients
چکیده انگلیسی
We found that hippocampal volume (HV) was decreased in FEP patients. Corrected right HV of FEP patients were significantly smaller compared to corrected right HVs of healthy subjects. The serum BDNF levels in the sample of FEP patients was significantly reduced compared to the healthy subjects. A significant positive association was found between serum BDNF and the corrected right HV in the group of patients such that the smaller the HV, the more reduced the serum BDNF levels. (Pearson r = 0.452, p = 0.045). Our findings indicate that low serum BDNF levels are associated with reduction in HV at the onset of schizophrenia and may further support the theory of a neuroprogressive-neurotoxic reaction associated with the onset of psychosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 129, Issues 2–3, July 2011, Pages 201-204
نویسندگان
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