کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6829170 548091 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients
چکیده انگلیسی
Meta-analysis recently suggested that a 5 μM increase in homocysteine is associated with a 70% higher risk for schizophrenia. Elevated homocysteine is reported to alter macromolecule methylation. We studied whether elevated plasma homocysteine levels in schizophrenia are associated with altered leukocyte global DNA methylation. DNA was extracted from peripheral blood leukocytes of 28 schizophrenia patients vs. 26 matched healthy controls. Percent of global genome DNA methylation was measured using the cytosine-extension method. Homocysteine levels were higher in schizophrenia patients than in controls. No difference in global DNA methylation between schizophrenia patients and control subjects was found (74.0% ± 14.8 vs. 69.4 ± 22.0, p = 0.31). A significant interaction between diagnosis and smoking on DNA methylation was obtained (F = 6.8, df = 1,47, p = 0.032). Although leukocytes may be a useful cell model to evaluate epigenetic changes such as global DNA methylation in brain, future studies should compare global DNA methylation in peripheral tissue vs. brain in laboratory animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 101, Issues 1–3, April 2008, Pages 50-57
نویسندگان
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