کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
69617 | 48782 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of aryl γ,δ-unsaturated β-hydroxyesters by ketoreductases
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
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چکیده انگلیسی
• The enzymatic reduction of aryl γ,δ-unsaturated-β-ketoesters to alcohols was evaluated.
• Both enantiomers of the alcohol were synthesized in >99% ee.
• The products are easily isolated and purified.
• The reactions are scalable with high optical purity and good yield.
The biocatalytic reduction of aryl γ,δ-unsaturated-β-ketoesters was evaluated utilizing 24 different commercially available ketoreductases. In all cases, both (R) and (S)-enantiomers of γ,δ-unsaturated β-hydroxyesters were synthesized by one or more ketoreductases in excellent optical purity and yields.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 97, 15 December 2013, Pages 264–269
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 97, 15 December 2013, Pages 264–269
نویسندگان
Zhipeng Dai, Kate Guillemette, Thomas K. Green,