Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib

• Cascade chemo-enzymatic reactions.
• Continuous flow Suzuki reactions for Odanacatib intermediate synthesis.
• Highly selective bioreduction of fluorinated acetophenone.

The development of chemo-enzymatic reaction under continuous flow conditions is an emerging area where biotechnology and organic chemistry can joint efforts in order to develop better process. Here in we report our effort on the development of a continuous flow approach to the synthesis of Odanacatib intermediate using a combined batch and continuous flow apparatus arriving on the desired molecule in excellent yields and selectivity.

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