کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
69642 | 48783 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib](/preview/png/69642.png)
چکیده انگلیسی
• Cascade chemo-enzymatic reactions.
• Continuous flow Suzuki reactions for Odanacatib intermediate synthesis.
• Highly selective bioreduction of fluorinated acetophenone.
The development of chemo-enzymatic reaction under continuous flow conditions is an emerging area where biotechnology and organic chemistry can joint efforts in order to develop better process. Here in we report our effort on the development of a continuous flow approach to the synthesis of Odanacatib intermediate using a combined batch and continuous flow apparatus arriving on the desired molecule in excellent yields and selectivity.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 104, June 2014, Pages 101–107
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 104, June 2014, Pages 101–107
نویسندگان
Raquel de Oliveira Lopes, Amanda S. de Miranda, Benedikt Reichart, Toma Glasnov, C. Oliver Kappe, Robert C. Simon, Wolfgang Kroutil, Leandro S.M. Miranda, Ivana C.R. Leal, Rodrigo O.M.A. de Souza,