(Chemo)enzymatic cascades—Nature's synthetic strategy transferred to the laboratory

• Cascade sequences of biotransformations are a key aspect of nature's synthetic strategy.
• Multi-enzymatic and chemo-enzymatic cascades attract increasing interest in biocatalysis.
• The term ‘cascade’ is broadly used for a variety of biocatalytic one-pot systems.
• This Special Issue covers many aspects and advantages of (chemo)enzymatic cascades.

The astonishing efficiency with which living organisms build complex molecules from simple starting materials has inspired chemists for centuries. Among the synthetic strategies that nature uses to achieve this efficiency, the combination of several enzymatic transformations in cascading sequences is of outstanding importance. With the rise of biocatalysis, researchers now have the tools at hand to mimic this strategy and develop artificial enzyme cascades of impressive complexity. This editorial review aims to introduce the reader to some key aspects of (chemo)enzymatic cascades, as well as to put the submissions to the present Special Issue into a broader context.

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